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Participanții au avut o vârstă medie de 35 de ani; 72% erau bărbați și 79% consumau heroină. Au fost randomizați la 2,88 mg (n = 229) sau 2,16 mg (n = 356) de lofexidină sau placebo (n = 281).

Aproximativ 41% dintre persoanele din grupurile de lofexidină au finalizat perioada de tratament, comparativ cu 28% din grupul placebo. Scorurile la scara scurtă de retragere a opiaceelor ​​din Gossop, o evaluare evaluată subiect, au indicat o reducere mai mare a simptomelor de sevraj în ambele grupuri de lofexidină comparativ cu placebo (P

Lofexidina este similară cu clonidina, care este utilizată off-label pentru a trata simptomele de sevraj la opioide. "Clonidina nu este aprobată de FDA și lipsește ghiduri de dozare standardizate, bazate pe dovezi, pentru gestionarea retragerii opioidelor," Spuse Pirner. Lofexidina are informații de prescriere și siguranță definite în mod clar, susținute de revizuirea și aprobarea FDA, care are "potențialul de a schimba modul în care pacienții și clinicienii se adresează" retragere, a adăugat el.

În timp ce clonidina este generică și ieftină, "lofexidina poate fi superioară în ceea ce privește un profil suganorm ro de efect secundar mai bun și o tensiune arterială mai mică, care este principala limitare a utilizării pe termen scurt a clonidinei," a remarcat Joshua Lee, MD, de la Universitatea din New York Langone Health din New York.

Dar "cea mai mare problemă este dacă plătitorii și furnizorii vor folosi sau simt că trebuie să folosească un nou și relativ scump agonist alfa-2, acum etichetat FDA pentru tratamentul non-opioid al retragerii opioidelor," Lee, care nu a fost implicat în studiu, a declarat pentru MedPage Today.

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